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The growth properties of twelve different amber (am ) mutants of bacteriophage T4 gene 43 (DNA polymerase) were examined by using nonpermissive (su − ) as well as permissive (su + )Escherichia coli hosts. It was found that most of these mutants were measurably suppressed insu − hosts by translational ambiguity (misreading of codons during protein synthesis). The ability of these mutants to grow in response to this form of weak suppression probably means that the T4 gene 43 DNA polymerase can be effective in supporting productive DNA replication when it is supplied in small amounts. By similar criteria, studies with other phage mutants suggested that the products of T4 genes 62 (uncharacterized), 44 (uncharacterized), 42 (dCMP-hydroxymethylase), and 56 (dCTPase) are also effective in small amounts. Some T4 gene products, such as the product of gene 41 (uncharacterized), seem to be partially dispensable for phage growth sinceam mutants of such genes do propagate, although weakly, in streptomycin-resistantsu − hosts which appear to have lost the capacity to suppressam mutations by ambiguity.

Suppression of Amber Mutations of Bacteriophage T4 Gene 43 (DNA Polymerase) by Translational Ambiguity