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Four new nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid viruses have been isolated. Although these viruses (designated Ad2+ ND2 , Ad2+ ND3 , Ad2+ ND4 , and Ad2+ ND5 ) were clonal derivatives of the same Ad2-SV40 hybrid population, they differ significantly from each other and from the previously isolated nondefective hybrid, Ad2+ ND1 , in their biological properties or in the amount of SV40-specific RNA induced during lytic infection.Like Ad2+ ND1 , Ad2+ ND2 , and Ad2+ ND4 pass serially in both human embryonic kidney (HEK) and primary African green monkey kidney cells. In contrast, Ad2+ ND3 and Ad2+ ND5 pass serially only in HEK cells. Ad2+ ND2 is like Ad2+ ND1 in that it induces the SV40 U antigen, but not SV40 T antigen; however, in contrast to the perinuclear SV40 antigen induced by Ad2+ ND1 , the SV40 antigen induced by Ad2+ ND2 is located peripherally in the cytoplasm as well as in the perinuclear region of infected cells. Ad2+ ND4 induces both the SV40 T and U antigens. Ad2+ ND3 and Ad2+ ND5 do not induce serologically detectable SV40 antigens and are distinguished from each other on the basis of the relative quantities of SV40-specific RNA which they induce. The induction of different SV40-specific functions suggests the incorporation of different segments of SV40 DNA within the genomes of the respective hybrid viruses.

journal of virology

Studies of Nondefective Adenovirus 2-Simian Virus 40 Hybrid Viruses V. Isolation of Additional Hybrids Which Differ in Their Simian Virus 40-Specific Biological Properties