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Formation of hybrids between viral deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) was used to detect virus-specific RNA in the nuclei and polyribosomes of transformed and tumor cells induced by "highly" oncogenic human adenovirus (Ad) types 12, 18, and 31. The presence of virus-specific RNA in the cell nucleus, and the inhibitory effect of actinomycin D on its synthesis, suggest that adenovirus-specific RNA is transcribed from a DNA template in the nucleus. Ad 12, 18, and 31 virus-specific RNA did not hybridize significantly with the DNA of the "weakly" oncogenic adenovirus group (Ad 3, 7, 11, 14, 16, and 21) or with that of nononcogenic Ad 2 and 4. Labeled RNA from Ad 12, 18, and 31 tumor cells hybridized with heterologous Ad 12, 18, and 31 DNA 30 to 60% as efficiently as with homologous DNA. Thus, common viral genes are transcribed in tumor cells induced by Ad 12, 18, and 31.

journal of virology

Mechanism of Viral Carcinogenesis by Deoxyribonucleic Acid Mammalian Viruses IV. Related Virus-specific Ribonucleic Acids in Tumor Cells Induced by “Highly” Oncogenic Adenovirus Types 12, 18, and 31