Open AccessMyxoma Virus M064 Is a Novel Member of the Poxvirus C7L Superfamily of Host Range Factors That Controls the Kinetics of Myxomatosis in European Rabbits
Author(s) -
Jia Liu,
Sonia Wennier,
Nissin Moussatché,
Mary K. Reinhard,
Richard Condit,
Grant McFadden
Publication year - 2012
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.06933-11
Subject(s) - myxomatosis , myxoma virus , biology , poxviridae , virology , european rabbit , virus , myxoma , host (biology) , ecology , genetics , recombinant dna , gene , sociology , population , medicine , cardiology , vaccinia , demography
The myxoma virus (MYXV) carries three tandem C7L-like host range genes (M062R, M063R, and M064R). However, despite the fact that the sequences of these three genes are similar, they possess very distinctive functions in vivo. The role of M064 in MYXV pathogenesis was investigated and compared to the roles of M062 and M063. We report that M064 is a virulence factor that contributes to MYXV pathogenesis but lacks the host range properties associated with M062 and M063.
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