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It has recently been shown that polymorphism at the rhesus macaqueTRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show thatTRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing theTRIM5 TFP andTRIM5 CypA alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing otherTRIM5 allele combinations. Our results indicate that theTRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses.

journal of virology

The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge