Open AccessCapacity for Infectious HIV-1 Virion Capture Differs by Envelope Antibody Specificity
Author(s) -
Pinghuang Liu,
LaTonya D. Williams,
Xiaoying Shen,
Mattia Bonsignori,
Nathan Vandergrift,
R. Glenn Overman,
M. Anthony Moody,
Hua-Xin Liao,
Daniel J Stieh,
Kerrie L. McCotter,
Audrey L. French,
Thomas J. Hope,
Robin J. Shattock,
Barton F. Haynes,
Georgia D. Tomaras
Publication year - 2014
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.03765-13
Subject(s) - virology , biology , antibody , virus , human immunodeficiency virus (hiv) , neutralizing antibody , neutralization , immunology
Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.
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