Open AccessExpression Profile of MicroRNAs in Epstein-Barr Virus-Infected AGS Gastric Carcinoma Cells
Author(s) -
Aron R. Marquitz,
Anuja Mathur,
Pauline Chugh,
Dirk P. Dittmer,
Nancy RaabTraub
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02662-13
Subject(s) - biology , microrna , epstein–barr virus , downregulation and upregulation , virus , suppressor , virology , latent virus , cancer research , microbiology and biotechnology , gene , genetics
Latent infection with Epstein-Barr virus (EBV) is responsible for multiple types of malignancies, including 10% of all gastric carcinomas. The microRNA (miRNA) expression in several EBV-infected AGS gastric carcinoma cell lines was determined. Infected cells expressed the viral BamHI A rightward transcript (BART) miRNAs at high levels and had consistently decreased expression of a small fraction of cellular miRNAs with specific downregulation of tumor suppressor miRNAs. These changes likely reflect expression of the viral noncoding RNAs and not latent protein expression.
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