Open AccessViral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands
Author(s) -
Wiebke Handke,
Christina Luig,
Branka Popović,
Astrid Krmpotić,
Stipan Jonjić,
Wolfram Brune
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02657-12
Subject(s) - biology , virology , cytomegalovirus , mediator , in vivo , virus , viral replication , apoptosis , titer , viral interference , viral pathogenesis , viral evolution , human cytomegalovirus , microbiology and biotechnology , viral disease , herpesviridae , rna , gene , genetics
Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1(-/-) mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.
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