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Alphabaculoviruses are lepidopteran-specific nucleopolyhedroviruses that replicate within the nucleus; however, the anterograde transport of the nucleocapsids of these viruses, which is an obligatory step for progeny virion production, is not well understood. In the present study, a uniqueAlphabaculovirus gene with unknown function, namely, the Autographa californica multiple nucleopolyhedrovirus (AcMNPV)ac51 gene, was found to be required for efficient nuclear egress of AcMNPV nucleocapsids.

journal of virology

The Autographa californica Multiple Nucleopolyhedrovirus <i>ac51</i> Gene Is Required for Efficient Nuclear Egress of Nucleocapsids and Is Essential for <i>In Vivo</i> Virulence

The Autographa californica Multiple Nucleopolyhedrovirus ac51 Gene Is Required for Efficient Nuclear Egress of Nucleocapsids and Is Essential for In Vivo Virulence