Open AccessKaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation
Author(s) -
Qiming Liang,
Brian Chang,
Kevin Brulois,
Kamilah Castro,
ChanKi Min,
Mary A. Rodgers,
Mude Shi,
Jianning Ge,
Pinghui Feng,
ByungHa Oh,
Jae U. Jung
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01898-13
Subject(s) - autophagy , biology , autophagosome , microbiology and biotechnology , innate immune system , signal transduction , virology , immunity , immune system , immunology , genetics , apoptosis
Autophagy is an important innate safeguard mechanism for protecting an organism against invasion by pathogens. We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.
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