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While Friend retrovirus-infected mice readily mount a vigorous CD8+ T cell response to the leader-gag-derived peptide GagL85–93 , no GagL85–93 -specific T cells were detectable in mice immunized against Friend virus (FV) with viral vectors or DNA vaccines. By exchanging one epitope-flanking amino acid or using a scaffold protein we were able to demonstrate for the first time the induction of GagL85–93 -specific CD8+ T cells by genetic vaccination and show their high protective effect against FV challenge infection.

journal of virology

Modification of One Epitope-Flanking Amino Acid Allows for the Induction of Friend Retrovirus-Specific CD8<sup>+</sup>T Cells by Adenovirus-Based Immunization

Modification of One Epitope-Flanking Amino Acid Allows for the Induction of Friend Retrovirus-Specific CD8+T Cells by Adenovirus-Based Immunization

Modification of One Epitope-Flanking Amino Acid Allows for the Induction of Friend Retrovirus-Specific CD8⁺T Cells by Adenovirus-Based Immunization