Open AccessThe Secreted G Protein of Human Respiratory Syncytial Virus Antagonizes Antibody-Mediated Restriction of Replication Involving Macrophages and Complement
Author(s) -
Alexander Bukreyev,
Lijuan Yang,
Peter L. Collins
Publication year - 2012
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01162-12
Subject(s) - biology , virology , antibody , glycoprotein , neutralization , antibody dependent enhancement , virus , antigen , complement system , complement receptor , viral replication , immunology , microbiology and biotechnology
The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restrictionin vivo , and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.
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