Open AccessCrawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants
Author(s) -
Dahui You,
Jordy Saravia,
David Siefker,
Bishwas Shrestha,
Stephania A. Cormier
Publication year - 2015
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01026-15
Subject(s) - biology , virus , virology , respiratory system , pathogenesis , immune system , crawling , immunology , physiology , anatomy
The infant immune response to respiratory syncytial virus (RSV) remains incompletely understood. Here we review the use of a neonatal mouse model of RSV infection to mimic severe infection in human infants. We describe numerous age-specific responses, organized by cell type, observed in RSV-infected neonatal mice and draw comparisons (when possible) to human infants.
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