Articles of Significant Interest Selected from This Issue by the Editors

Adenovirus E1A is a potent transcriptional activator widely used to study control of transcriptional initiation. E1A functions through subversion and repurposing of cellular factors. Fonseca et al. (p. 5630 –5637) describe a process by which E1A recruits the human Bre1 and Paf1 chromatin-modification complexes to viral genes to enhance transcriptional elongation by RNA polymerase II. This study reveals a new mechanism employed by E1A to stimulate viral transcription, which functions at the level of transcriptional elongation.