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Lymphocytes with the regulatory CD4+ CD25+ phenotype frequently suppress memory T-cell responses. Murine herpes simplex virus type 1 (HSV-1) models have shown that CD4+ CD25+ cells can limit immunity-mediated corneal damage but slow viral clearance. We investigated the effect of CD4+ CD25+ cells from healthy HSV-2-infected humans on recall proliferative (CD4) responses to HSV-2. Depletion and reconstitution experiments were consistent with a suppressive effect of autologous blood-derived CD4+ CD25+ cells for whole HSV-2 antigen. Regulatory T cells may modulate human CD4 memory responses to HSV-2 and influence their antiviral and inflammatory functions.

Human CD4 + CD25 high Cells Suppress Proliferative Memory Lymphocyte Responses to Herpes Simplex Virus Type 2

Human CD4 ⁺ CD25 ^high Cells Suppress Proliferative Memory Lymphocyte Responses to Herpes Simplex Virus Type 2