Open AccessIdentification of the First Human Gyrovirus, a Virus Related to Chicken Anemia Virus
Author(s) -
Virginie Sauvage,
Justine Cheval,
Vincent Foulongne,
Meriadeg Ar Gouilh,
Kevin Pariente,
Jean Claude Manuguerra,
Jennifer Richardson,
O. Dereure,
Marc Lecuit,
Ana Maria Burguière,
Valérie Caro,
Marc Éloit
Publication year - 2011
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00639-11
Subject(s) - virus , virology , biology , feces , anemia , apoptosis , novel virus , gene , medicine , microbiology and biotechnology , genetics , genome
We have identified in a skin swab sample from a healthy donor a new virus that we have named human gyrovirus (HGyV) because of its similarity to the chicken anemia virus (CAV), the only previously known member of the Gyrovirus genus. In particular, this virus encodes a homolog of the CAV apoptin, a protein that selectively induces apoptosis in cancer cells. By PCR screening, HGyV was found in 5 of 115 other nonlesional skin specimens but in 0 of 92 bronchoalveolar lavages or nasopharyngeal aspirates and in 0 of 92 fecal samples.
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