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The mosquitoAedes aegypti transmits a number of arthropod-borne viruses (arboviruses), such as dengue virus and Zika virus. Mosquitoes also harbor insect-specific viruses that may affect replication of pathogenic arboviruses in their body. Currently, however, there are only a few insect-specific viruses described fromA. aegypti in the literature. Here, we characterize a novel negative-strand virus, AeAV. Meta-analysis ofA. aegypti samples showed that it is present inA. aegypti mosquitoes worldwide and is vertically transmitted.Wolbachia -transinfected mosquitoes are currently being used in biocontrol, as they effectively block transmission of several positive-sense RNA viruses in mosquitoes. Our results demonstrate thatWolbachia enhances the replication of AeAV and modestly reduces dengue virus replication in a cell line model. This study expands our understanding of the virome inA. aegypti as well as providing insight into the complexity of theWolbachia virus restriction phenotype.

journal of virology

Aedes Anphevirus: an Insect-Specific Virus Distributed Worldwide in Aedes aegypti Mosquitoes That Has Complex Interplays with Wolbachia and Dengue Virus Infection in Cells