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The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.

journal of clinical microbiology

Emergence of a Clinical Daptomycin-Resistant <i>Staphylococcus aureus</i> Isolate during Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia and Osteomyelitis

Emergence of a Clinical Daptomycin-Resistant Staphylococcus aureus Isolate during Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Osteomyelitis