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We amplified by PCR and sequenced Streptococcus pneumoniae rpoB from DNA of the cardiac valve of a man who had presented with pneumococcal endocarditis 7 years earlier. Histopathologically, the valve did not show evidence of endocarditis. This case raises the question of persistence of DNA without any evidence of infection.

Streptococcus pneumoniae Endocarditis: Persistence of DNA on Heart Valve Material 7 Years after Infectious Episode