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A mutation (C-to-T transition) at position 491 of the rrs gene was identified in a Mycobacterium tuberculosis strain family (n = 208 isolates) that was predominant in a suburb of Cape Town, South Africa. This nucleotide change is not involved in streptomycin resistance, and we suggest caution in assuming that all mutations in genes targeted by antituberculosis drugs confer drug resistance.

journal of clinical microbiology

Sequence Polymorphism in the <i>rrs</i> Gene of <i>Mycobacterium tuberculosis</i> Is Deeply Rooted within an Evolutionary Clade and Is Not Associated with Streptomycin Resistance

Sequence Polymorphism in the rrs Gene of Mycobacterium tuberculosis Is Deeply Rooted within an Evolutionary Clade and Is Not Associated with Streptomycin Resistance