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Previous epidemiological studies ofChlamydia trachomatis frequently have required expansion of isolates in tissue culture. The possibility thatC. trachomatis omp1 might undergo mutation during such expansion has not been examined systematically. We found no differences in theomp1 sequences from 10 clinical specimens before and after 20 in vitro passages.

Effect of Serial Passage in Tissue Culture on Sequence ofomp1fromChlamydia trachomatisClinical Isolates