Open AccessAn Enhanced DNA Fingerprinting Service To Investigate Potential Clostridium difficile Infection Case Clusters Sharing the Same PCR Ribotype
Author(s) -
Warren N. Fawley,
Mark H. Wilcox
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.05873-11
Subject(s) - clostridium difficile , dna profiling , ribotyping , microbiology and biotechnology , biology , outbreak , polymerase chain reaction , multilocus sequence typing , clostridiaceae , molecular epidemiology , genetics , virology , genotype , dna , antibiotics , gene , toxin
Of 53 potentialClostridium difficile infection (CDI) case clusters/outbreaks, affecting 2 to 41 patients in 27 institutions, 19% comprised unrelated isolates and 34% had highly related and distinct isolates as shown by multilocus variable-number tandem-repeat analysis, despite sharing a common ribotype. These findings emphasize the value of enhanced fingerprinting to confirm or refute suspected CDI case clusters.
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