Open AccessPerformance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis
Author(s) -
Anupop Jitmuang,
Anil A. Panackal,
Peter R. Williamson,
John E. Bennett,
John P. Dekker,
Adrian M. Zelazny
Publication year - 2015
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.02223-15
Subject(s) - cryptococcosis , latex fixation test , antigen , cryptococcus neoformans , titer , immunology , virology , cryptococcal meningitis , biology , cryptococcus , human immunodeficiency virus (hiv) , mycosis , agglutination (biology) , microbiology and biotechnology , viral disease , antibody
The cryptococcal antigen lateral flow assay (CrAg LFA) was evaluated for the diagnosis of cryptococcosis in HIV-negative patients. The sensitivity was excellent, suggesting that this assay can replace conventional testing based on latex agglutination (LA). CrAg LFA and LA titers were correlated but were not directly comparable, with implications for conversion between assays.
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