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Of 38 vancomycin-intermediateStaphylococcus aureus (VISA) clinical strains, 27 (71%) possessed a mutation(s) inrpoB encoding the β-subunit of RNA polymerase. Furthermore, 95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistantS. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of anrpoB mutation in VISA phenotype expression.

Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus