Open AccessUltrasensitive Detection of Clostridium difficile Toxins Reveals Suboptimal Accuracy of Toxin Gene Cycle Thresholds for Toxin Predictions
Author(s) -
Johanna Sandlund,
Mark H. Wilcox
Publication year - 2019
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01885-18
Subject(s) - clostridium difficile , nucleic acid amplification tests , overdiagnosis , toxin , clostridium difficile toxin a , microbiology and biotechnology , clostridium , biology , clostridioides , clostridium difficile toxin b , microbial toxins , loop mediated isothermal amplification , clostridium infections , virology , medicine , bacteria , genetics , pathology , dna , antibiotics , chlamydia trachomatis
The use of nucleic acid amplification tests (NAATs) for the diagnosis ofClostridium (Clostridioides )difficile infection (CDI) leads to overdiagnosis. To improve the clinical specificity of NAATs, there has been a recent interest in using toxin gene cycle thresholds (CT s) to predict the presence and absence of toxins.
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