Open AccessHelicobacter pylori Mutations Detected by Next-Generation Sequencing in Formalin-Fixed, Paraffin-Embedded Gastric Biopsy Specimens Are Associated with Treatment Failure
Author(s) -
Behtash Ghazi Nezami,
Mehul Jani,
David Alouani,
Daniel D. Rhoads,
Navid Sadri
Publication year - 2019
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01834-18
Subject(s) - helicobacter pylori , gastric biopsy , biopsy , pathology , helicobacter infections , biology , spirillaceae , dna sequencing , microbiology and biotechnology , medicine , gastritis , gene , genetics
Helicobacter pylori antibiotic resistance is widespread and increasing worldwide. Routine detection ofH. pylori mutations that invoke antimicrobial resistance may be a useful approach to guide antimicrobial therapy and possibly avert treatment failure.
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