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Cytauxzoon felis, an emerging virulent protozoan parasite that infects domestic cats, is treated with atovaquone and azithromycin (A&amp;A). Atovaquone targets parasite cytochrome b. We characterized the C. felis cytochrome b gene (cytb) in cats with cytauxzoonosis and found a cytb genotype that was associated with survival in A&amp;A-treated cats.

Pharmacogenomics of Cytauxzoon felis Cytochrome b : Implications for Atovaquone and Azithromycin Therapy in Domestic Cats with Cytauxzoonosis