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We used 909 strains to compare the population structures of theMycobacterium tuberculosis Beijing family between different birth-year cohorts in Japan. The results revealed that the spread of a modern sublineage that has high transmissibility is currently increasing, while the spread of an ancient sublineage, STK, has significantly decreased in younger generations.

Population Structure Dynamics of Mycobacterium tuberculosis Beijing Strains during Past Decades in Japan