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In persons with cystic fibrosis (CF), airway infection withBurkholderia cepacia complex (Bcc) species orBurkholderia gladioli presents a significant challenge due to inherent resistance to multiple antibiotics. Two chromosomally encoded inducible β-lactamases, a Pen-like class A and AmpC are produced in Bcc andB. gladioli .

journal of clinical microbiology

“Switching Partners”: Piperacillin-Avibactam Is a Highly Potent Combination against Multidrug-Resistant <i>Burkholderia cepacia</i> Complex and <i>Burkholderia gladioli</i> Cystic Fibrosis Isolates

“Switching Partners”: Piperacillin-Avibactam Is a Highly Potent Combination against Multidrug-Resistant Burkholderia cepacia Complex and Burkholderia gladioli Cystic Fibrosis Isolates