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We aimed to detect the etiological agents of acute diarrhea by a molecular gastrointestinal pathogen test (MGPT) and to assess the impact of MGPT on antimicrobial stewardship programs (ASP). This is a prospective observational study and was conducted between 1 January 2015 and 30 June 2017. We included consequent patients who had acute diarrhea. At the end of 2015, we implemented ASP in acute diarrhea cases and compared the outcomes in the pre-ASP and post-ASP periods. An FDA-cleared multiplexed gastrointestinal PCR panel system, the BioFire FilmArray (Idaho Technology, Salt Lake City, UT), which detects 20 pathogens in stool, was used. In 499 out of 699 patients (71%), at least one pathogen was detected. Among 314 adults with positive MGPT, 101 (32%) enteropathogenicEscherichia coli (EPEC), 71 (23%) enteroaggregativeE. coli (EAEC), 68 (22%) enterotoxigenicE. coli (ETEC), 55 (18%) Shiga toxin-producingE. coli (STEC) (17%)Norovirus , 48 (15%)Campylobacter , 21 (7%)Salmonella , and 20 (6%)Clostridium difficile strains were detected. Among 185 children, 55 (30%) EPEC, 37 (20%)C. difficile , 32 (17%)Norovirus , 29 (16%) EAEC, 22 (12%) STEC, 21 (11%) ETEC, 21 (11%)Campylobacter , 20 (11%)Salmonella , and 16 (5%)Rotavirus strains were detected. Inappropriate antibiotic use decreased in the post-ASP period compared with the pre-ASP period among inpatients (42.9% and 25.8%, respectively;P = 0.023). Using MGPT in clinical practice significantly decreased the unnecessary use of antibiotics. Detection of high rates ofC. difficile in children andSalmonella spp., as well as relatively high rates ofCampylobacter spp., which were hard to isolate by routine stool culture, were remarkable.

Rapid Molecular Detection of Gastrointestinal Pathogens and Its Role in Antimicrobial Stewardship