Open AccessInfluence of Acanthamoeba Genotype on Clinical Course and Outcomes for Patients with Acanthamoeba Keratitis in Spain
Author(s) -
Francisco ArnalichMontiel,
Blanca Lumbreras-Fernández,
Carmen M. Martín-Navarro,
Basilio Valladares,
Rogelio LópezVélez,
Rafael Morcillo-Laiz,
Jacob LorenzoMorales
Publication year - 2014
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00031-14
Subject(s) - acanthamoeba , acanthamoeba keratitis , genotype , keratitis , microbiology and biotechnology , biology , medicine , dermatology , genetics , gene
Genotype T4 is by far the most frequent genotype ofAcanthamoeba keratitis (AK) and therefore has been considered the most virulent. This study included 14 cases of AK of genotype T4 and three cases of non-T4 genotype. We found that cases of non-T4 genotype had a worse response to medical therapy, greater need for surgical intervention, greater risk of extracorneal involvement, and remarkably poorer final visual outcome than those of T4 genotype, suggesting an association betweenAcanthamoeba virulence and genotype that requires additional case investigation.
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