Open AccessNonproteolytic, AvirulentBacillus anthracisas a Live Vaccine
Author(s) -
Ernest S. Fubra
Publication year - 1966
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.91.3.930-933.1966
Subject(s) - bacillus anthracis , biology , anthrax vaccines , immunization , microbiology and biotechnology , vaccination , attenuated vaccine , strain (injury) , virology , bacillus (shape) , bacteria , virulence , antigen , immunology , genetics , gene , anatomy , biochemistry , dna vaccination
Fubra, Ernest S. (Federal Department of Veterinary Research, Vom, Nigeria). Nonproteolytic, avirulentBacillus anthracis as a live vaccine. J. Bacteriol.91: 930–933. 1966.—A nonproteolytic mutant, derived from the Sterne strain ofBacillus anthracis by exposure to ultraviolet radiation, was used for vaccination of guinea pigs. Vaccine prepared from the parent Sterne strain was used in comparable immunization procedure. Comparison of the protection induced by the two vaccines showed that use of the nonproteolytic mutant was from 10 to 1,000 times as effective as the Sterne strain.
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