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Tankersley, Robert W., Jr. (Medical College of Virginia, Richmond). Amino acid requirements of herpes simplex virus in human cells. J. Bacteriol. 87:609-613. 1964.-Progressive infection of human cells minimally infected with herpes simplex virus requires 11 of the amino acids of Eagle's medium, and glutamine. Lysine is not required, but rather exerts a partially inhibitory effect upon virus multiplication. Infected cells deprived of arginine support neither cytopathogenic effects nor virus replication; when arginine is replaced, a prompt and extensive infection follows. The effect of nutritional deficiencies on virus infection is discussed.

AMINO ACID REQUIREMENTS OF HERPES SIMPLEX VIRUS IN HUMAN CELLS