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where K1 and n are constants, C is the concentration of antigen and Ab is the antibody response. He found that aqueous influenza antigens, given relations (Stille, Woolridge, and Gundelfinger, J. Lab. Clin. Med., 53, 751, 1959). The least square line, fitted to the data for average change in titer tubes (or log antibody response) and log dose (in chick-cell agglutinating units) of table 1 gives regression coefficients of 0.219 for the subcutaneous route and 0.057 for the intracutaneous route. These slopes give values of n of 4.6 and 17.4 for the Smith and St. Johns-

INFLUENZA ANTIGEN DOSE AND ANTIBODY RESPONSE RELATIONSHIPS