English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Pittillo and Foster (1954) demonstrated that it is possible on a rational basis to formulate synergistic combinations of inhibitors for any particular bacterium. Prediction of combinations of inhibitors which are apt to be synergistic depends upon knowledge that the suppression of bacterial growth caused by individual inhibitors can be reversed by corresponding essential metabolites. Reversal by a particular metabolite implies that the inhibitor in question prevents growth by interfering with a biochemical pathway involving that metabolite, e. g., its synthesis, utilization, or penetration (see Cowan and Rowatt, 1958, for general review). The ideal situation, several instances of which have been already described (Foster and Pittillo, 1953b; Pittillo and Foster, 1954), is where the inhibitor blocks the biosynthesis of the metabolite. Chemically dissimilar inhibitors whose effects are reversible by the same metabolite probably interfere at different sites on a common pathway. When the two inhibitors are present simultaneously, the effects of each theoretically should be mutually potentiated. Beerstecher and Shive (1947) and Potter (1951) showed how one kind of synergism (sequential blocking) can be achieved by metabolite analogues whose sites of action are known, and where detailed knowledge of the pathways involved is available. This approach to synergism-the combination testing, both in vitro and in vivo, of pairs of metabolite analogueshas been very extensively exploited in recent years. Notwithstanding the discovery of a significant number of synergistically acting combinations (Lacey, 1958), the great majority of randomly paired analogues do not display this

FURTHER STUDIES ON POTENTIATION OF INHIBITOR ACTION THROUGH DETERMINATION OF REVERSING METABOLITES