English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

As long as man, the chimpanzee and the monkey are the only species in which enteric shigella infections can be studied, progress in problems concerning the pathogenesis of and immunity to bacillary dysentery will be seriously hanmpered. In recent years, successful attempts have been made to modify small laboratory animals in such ways as to make them susceptible to orally administered enteric pathogens. Thus Freter (1955) and Lowenthal (1953, personal communication), working independently, employed virtually identical methods to produce fatal infections in guinea pigs with orally administered cultures of Vibrio comma. The procedure involved starving the animal for four days and administering calcium carbonate prior to, and opium following, oral challenge. To modify the normal intestinal flora further, Freter treated his animals with streptomycin and used a streptomycin-resistant culture for challenge. Lowenthal found, however, that with the bacterial cultures and animals which he employed, treatment with streptomycin did not render the animals more susceptible. More recently Freter (1956) has described a long-term, nonfatal infection with either V. comma or Shigella flexneri 2a in guinea pigs which had been both (a) starved for 36 of the 48 hr prior to challenge, and (b) treated with antibiotics to alter the normal intestinal flora. No examination for intestinal lesions is mentioned in this report. Using Lowenthal's method, we have produced a fatal infection in guinea pigs with an orally administered suspension of S. flexneri 2a. This communication describes some of the characteristics of this infection.

EXPERIMENTAL SHIGELLA INFECTIONS: CHARACTERISTICS OF A FATAL INFECTION PRODUCED IN GUINEA PIGS