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Previous investigation of M'aruyama (1956) showed the dynamic aspects of biochemical changes occurring during synchronous growth of Escherichia coli. Similar results also were presented by other workers using similar bacteria (DeLamater, 1956; Barner and Cohen, 1956). In relation to these biochemical aspects it may be valuable to study the cellular response to chemical, physical, and biological antibacterial agents during cell growth. Bruce and Maal0e (1956) reported the effect of ultraviolet irradiation on synchronously dividing Salmonella typhimurium. Houtermans (1953) observed the effects of radiation on dividing E. coli. The infectivity of phage on the synchronously growing E. coli (thymineless mutant) also was reported by Barner and Cohen (1956). In these scattered reports the method of synchronization of microbial cultures was niot necessarily the same. Moreover, it is probable that some of the methods used in these studies might affect the normal metabolic pattern of cells due to a rather unnatural treatment of the original culture. In the present experiments, a physical method of synchronization was employed (Maruyama and Yanagita, 1956), which was considered to be milder than the others. Using this technique, the authors attempted to disclose the change in sensitivity of E. coli during growth. The effects of sodium cyanide, chloramphenicol, ultraviolet irradiation, as well as phage infection on the growing E. coli cells, were investigated with special reference to cytological observations.

CELLULAR RESPONSE TO DELETERIOUS AGENTS DURING THE COURSE OF SYNCHRONOUS GROWTH OF ESCHERICHIA COLI