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The emergence of drug resistant strains of tubercle bacilli has proved to be one of the main drawbacks to the successful use of antimicrobial therapy in pulmonary tuberculosis. Resistant strain also may be obtained readily by in vitro methods. Nevertheless, it has proven difficult to study this phenomenon experimentally because of the inability to induce regularly a high degree of drug resistance in cultures subjected to exposure to drugs in the animal body. This report summarizes the results of drug susceptibility determinations of several different strains of tubercle bacilli recovered from guinea pigs, mice, and rabbits after prolonged treatment.

journal of bacteriology

INFREQUENT APPEARANCE OF DRUG RESISTANT STRAINS OF TUBERCLE BACILLI IN EXPERIMENTAL ANIMALS TREATED WITH STREPTOMYCIN AND <i>p</i> -AMINO-SALICYLIC ACID,

INFREQUENT APPEARANCE OF DRUG RESISTANT STRAINS OF TUBERCLE BACILLI IN EXPERIMENTAL ANIMALS TREATED WITH STREPTOMYCIN AND p -AMINO-SALICYLIC ACID,