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Benzoic acid and some related compounds are able to increase the metabolism of mycobacteria (Bernheim, 1941). The oxygen uptake and carbon dioxide production of the pathogenic strains H-37 and B, are greatly accelerated when small amounts of benzoic or salicylic (o-hydroxybenzoic) acid are added to the bacterial suspensions. Other hydroxybenzoic acids as well as aminobenzoic acids are without effect. Benzoic and salicylic acid are not oxidized by these pathogenic strains, so presumably they act to catalyze some endogenous metabolic reaction of the cell. A Mycobacterium obtained from the collection of Dr. Van Niel, recently identified as M. lacticola, oxidizes benzoic, mand p-hydroxybenzoic acids but not salicylic acid (Bernheim, 1942). The first three acids can act as the sole carbon sources for the growth of this species (Saz and Bernheim, 1942). The metabolism of a number of other mycobacteria with respect to these compounds may be said to be intermediate between that of M. lacticola and the pathogenic strains in the sense that benzoic acid is oxidized by them but the hydroxy acids are not, although some of the latter may increase the oxygen uptake. Lehmann (1946) has found essentially the same effects in the mycobacteria he has studied. Because of the apparent importance of benzoic acid in the metabolism of these organisms, it was of interest to study the effects of streptomycin on its oxidation.

The Effect of Streptomycin on the Metabolism of Benzoic Acid by Certain Mycobacteria