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Until recently, only a dozen small RNAs that do not function as tRNAs or rRNAs were known for Escherichia coli . In the last 3 years, systematic screens based on computation, microarrays, and cloning have led to the discovery of more than 50 novel small-RNA (sRNA)-encoding genes in this bacterium ([

Regulatory Small RNAs: the Key to Coordinating Global Regulatory Circuits