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Expression of the Escherichia coli mutA mutator phenotype requires recA, recB, recC, ruvA, and ruvC gene, but not recD, recF, recO, or recR genes. Thus, the recBCD-dependent homologous recombination system is a component of the signal pathway that activates an error-prone DNA polymerase in mutA cells.

journal of bacteriology

Requirement for Homologous Recombination Functions for Expression of the <i>mutA</i> Mistranslator tRNA-Induced Mutator Phenotype in <i>Escherichia coli</i>

Requirement for Homologous Recombination Functions for Expression of the mutA Mistranslator tRNA-Induced Mutator Phenotype in Escherichia coli