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InBacillus subtilis , CcpA-dependent carbon catabolite repression (CCR) mediated at severalcis -acting carbon repression elements (cre ) requires the seryl-phosphorylated form of both the HPr (ptsH ) and Crh (crh ) proteins. During growth in minimal medium, theptsH1 mutation, which prevents seryl phosphorylation of HPr, partially relieves CCR of several genes regulated by CCR. Examination of the CCR of the histidine utilization (hut ) enzymes in cells grown in minimal medium showed that neither theptsH1 nor thecrh mutation individually had any affect onhut CCR but thathut CCR was abolished in aptsH1 crh double mutant. In contrast, theptsH1 mutation completely relievedhut CCR in cells grown in Luria-Bertani medium. TheptsH1 crh double mutant exhibited several growth defects in glucose minimal medium, including reduced rates of growth and growth inhibition by high levels of glycerol or histidine. CCR is partially relieved inB. subtilis mutants which synthesize low levels of active glutamine synthetase (glnA ). In addition, theseglnA mutants grow more slowly than wild-type cells in glucose minimal medium. The defects in growth and CCR seen in these mutants are suppressed by mutational inactivation of TnrA, a global nitrogen regulatory protein. The inappropriate expression of TnrA-regulated genes in this class ofglnA mutants may deplete intracellular pools of carbon metabolites and thereby result in the reduction of the growth rate and partial relief of CCR.

trans -Acting Factors Affecting Carbon Catabolite Repression of the hut Operon in Bacillus subtilis