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The ability to respond to ambient pH is critical to the growth and virulence of the fungal pathogenCandida albicans . This response entails the differential expression of several genes affecting morphogenesis. To investigate the mechanism of pH-dependent gene expression, theC. albicans homolog ofpacC , designatedPRR2 (for pH response regulator), was identified and cloned.pacC encodes a zinc finger-containing transcription factor that mediates pH-dependent gene expression inAspergillus nidulans . Mutants lackingPRR2 can no longer induce the expression of alkaline-expressed genes or repress acid-expressed genes at alkaline pH. Although the mutation did not affect growth of the cells at acid or alkaline pH, the mutants exhibited medium-conditional defects in filamentation.PRR2 was itself expressed in a pH-conditional manner, and its induction at alkaline pH was controlled byPRR1 .PRR1 is homologous topalF , a regulator ofpacC . Thus,PRR2 expression is controlled by a pH-dependent feedback loop. The results demonstrate that the pH response pathway ofAspergillus is conserved and that this pathway has been adapted to control dimorphism inC. albicans .

journal of bacteriology

Effect of Environmental pH on Morphological Development of <i>Candida albicans</i> Is Mediated via the PacC-Related Transcription Factor Encoded by <i>PRR2</i>

Effect of Environmental pH on Morphological Development of Candida albicans Is Mediated via the PacC-Related Transcription Factor Encoded by PRR2