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High-level expression of the major pilus subunit (PapA) of uropathogenic strains ofEscherichia coli results in part from the unusually long lifetime of the mRNA that encodes this protein. Here we report that the longevity ofpapA mRNA derives in large measure from the protection afforded by its 5′ untranslated region. ThispapA RNA segment can prolong the lifetime of an otherwise short-lived mRNA to which it is fused. In vivo alkylation studies indicate that, in its natural milieu, thepapA message begins with a stem-loop structure. This stem-loop is important for the stabilizing effect of thepapA 5′ untranslated region, as evidenced by the significant acceleration inpapA mRNA decay that results from its removal.

Importance of a 5′ Stem-Loop for Longevity of papA mRNA in Escherichia coli