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TheYersinia enterocolitica inv gene encodes the primary invasion factor invasin, which has been previously shown to be critical in the initial stages of infection. The expression ofinv is influenced by growth phase and temperature and is maximal during late exponential-early stationary phase at 23°C. In addition, motility ofY. enterocolitica is regulated by temperature.Y. enterocolitica cells are motile when grown at lower temperatures (30°C or below), while bacteria grown at 37°C are nonmotile. This study was initiated to determine the molecular basis for the temperature regulation ofinv expression. Two mutants were isolated that both showed a significant decrease in invasin expression but are hypermotile when grown at 23°C. The first mutant (JB1A8v) was a result of a random mTn5 Km insertion into theuvrC gene. TheuvrC mutant JB1A8v demonstrated a significant decrease ininv and an increase infleB (encodes flagellin) expression. These results suggest that expression ofinv and flagellin genes is coordinated at the level of transcription. The second regulatory mutant, JB16v, was a result of a targeted insertion into a locus similar tosspA which inE. coli encodes a stationary-phase regulator. TheE. coli sspA gene was cloned and assayed for complementation in both of the regulatory mutants. It was determined thatE. coli sspA restored invasin expression in both theuvrC mutant and thesspA mutant. In addition, the complementing clone decreased flagellin levels in these mutants.

Expression of Invasin and Motility Are Coordinately Regulated in Yersinia enterocolitica