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The modified nucleoside 2-methylthio-N -6-isopentenyl adenosine (ms2 i6 A) is present in position 37 (adjacent to and 3′ of the anticodon) of tRNAs that read codons beginning with U except tRNAI,V Ser inEscherichia coli . InSalmonella typhimurium , 2-methylthio-N -6-(cis -hydroxy)isopentenyl adenosine (ms2 io6 A; also referred to as 2-methylthiocis -ribozeatin) is found in tRNA, most likely in the species that have ms2 i6 A inE. coli . Mutants (miaE ) ofS. typhimurium in which ms2 i6 A hydroxylation is blocked are unable to grow aerobically on the dicarboxylic acids of the citric acid cycle. Such mutants have normal uptake of dicarboxylic acids and functional enzymes of the citric acid cycle and the aerobic respiratory chain. The ability ofS. typhimurium to grow on succinate, fumarate, and malate is dependent on the state of modification in position 37 of those tRNAs normally having ms2 io6 A37 and is not due to a second cellular function of tRNA (ms2 io6 A37)hydroxylase, themiaE gene product. We suggest thatS. typhimurium senses the hydroxylation status of the isopentenyl group of the tRNA and will grow on succinate, fumarate, or malate only if the isopentenyl group is hydroxylated.

The ms 2 io 6 A37 Modification of tRNA in Salmonella typhimurium Regulates Growth on Citric Acid Cycle Intermediates

The ms ² io ⁶ A37 Modification of tRNA in Salmonella typhimurium Regulates Growth on Citric Acid Cycle Intermediates