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Expression of theEscherichia coli multiple antibiotic resistancemarA gene cloned inMycobacterium smegmatis produced increased resistance to multiple antimicrobial agents, including rifampin, isoniazid, ethambutol, tetracycline, and chloramphenicol. ClonedmarR ormarA cloned in the antisense direction had no effect. Resistance changes were lost with spontaneous loss of the plasmid bearingmarA . A MarA mutant protein, having an insertional mutation within either of its two alpha-helices of the first putative helix-turn-helix domain, failed to produce the multiresistance phenotype inE. coli andM. smegmatis , indicating that this region is critical for MarA function. These results strongly suggest thatE. coli marA functions inM. smegmatis and that amar -like regulatory system exists in this organism.

Multidrug Resistance following Expression of the Escherichia coli marA Gene in Mycobacterium smegmatis