Open AccessAn Epigenetic Switch Mediates Bistable Expression of the Type 1 Pilus Genes in Streptococcus pneumoniae
Author(s) -
A Basset,
Keith H. Turner,
Elizabeth Boush,
Sabina Sayeed,
Simon L. Dove,
Richard Malley
Publication year - 2011
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.06078-11
Subject(s) - pilus , biology , bistability , streptococcus pneumoniae , gene expression , microbiology and biotechnology , regulation of gene expression , epigenetics , gene , transcription factor , genetics , bacteria , escherichia coli , physics , quantum mechanics
Expression of the pneumococcal type 1 pilus is bistable and positively regulated by the transcription factor RlrA. RlrA is also known to positively control its own expression. Here we present evidence that bistable expression of the type 1 pilus is mediated by the positive-feedback loop controlling rlrA expression.
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