Open AccessEscherichia coliNucleoside Diphosphate Kinase Mutants Depend on Translesion DNA Synthesis To Prevent Mutagenesis
Author(s) -
Jared Nordman,
Andrew Wright
Publication year - 2011
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.05393-11
Subject(s) - biology , mutagenesis , mutant , escherichia coli , nucleoside diphosphate kinase , mutation , dna , biochemistry , uracil , dna synthesis , microbiology and biotechnology , kinase , gene
Escherichia coli nucleoside diphosphate (NDP) kinase mutants have an increased frequency of spontaneous mutation, possibly due to uracil misincorporation into DNA. Here we show that NDP kinase mutants are dependent on translesion DNA synthesis, often a mutagenic form of DNA synthesis, to prevent mutagenesis.