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The genes required for 3-hydroxybenzoate and gentisate catabolism inCorynebacterium glutamicum are closely clustered in three operons. GenR, an IclR-type regulator, can activate the transcription ofgenKH andgenDFM operons in response to 3-hydroxybenzoate and gentisate, and it can repress its own expression. Footprinting analyses demonstrated that GenR bound to four sites with different affinities. Two GenR-binding sites (DFMn01 and DFMn02) were found to be located between positions −41 and −84 upstream of the −35 and −10 regions of thegenDFM promoter, which was involved in positive regulation ofgenDFM transcription. The GenR binding site R-KHn01 (located between positions −47 and −16) overlapped the −35 region of thegenKH promoter sequence and is involved in positive regulation of its transcription. The binding site R-KHn02, at which GenR binds to its own promoter, was found within a footprint extending from position −44 to −67. It appeared to be involved in negative regulation of the activity of thegenR promoter. A consensus motif with a 5-bp imperfect palindromic sequence [ATTCC-N7(5) -GGAAT] was identified among all four GenR binding sites and found to be necessary to GenR regulation through site-directed mutagenesis. The results reveal a new regulatory function of the IclR family in the catabolism of aromatic compounds.

journal of bacteriology

GenR, an IclR-Type Regulator, Activates and Represses the Transcription of <i>gen</i> Genes Involved in 3-Hydroxybenzoate and Gentisate Catabolism in Corynebacterium glutamicum

GenR, an IclR-Type Regulator, Activates and Represses the Transcription of gen Genes Involved in 3-Hydroxybenzoate and Gentisate Catabolism in Corynebacterium glutamicum